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caspase-3

Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation

[Oxidative Medicine and Cellular Longevity] In order to discover novel endothelial-specific receptor tyrosine kinases (VEGFR)-2 TK inhibitors, scientists designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines.

RvD1 Accelerates the Resolution of Inflammation by Promoting Apoptosis of the Recruited Macrophages via the ALX/FasL-FasR/Caspase-3 Signaling Pathway

[Cell Death Discovery] Mice were administered Resolvin D1 via the tail vein 3 and 4 days after stimulation with lipopolysaccharide.

Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats

[Stem Cell International] Scientists determined whether human umbilical cord blood platelet-rich plasma (ucPRP) enhances the beneficial effects of HucMSCs in the treatment of POF.

CD157 Signaling Promotes Survival of Acute Myeloid Leukemia Cells and Modulates Sensitivity to Cytarabine through Regulation of Anti-apoptotic Mcl-1

[Scientific Reports] Investigators used peripheral blood and bone marrow samples from patients with acute myeloid leukemia (AML) to analyze the impact of CD157-directed antibodies in AML survival and in response to cytarabine ex vivo.

Moracin D Induces Apoptosis in Prostate Cancer Cells via Activation of PPAR Gamma/PKC Delta and Inhibition of PKC Alpha

[Phytotherapy Research] Researchers explored the apoptotic mechanism of Moracin D in prostate cancer cells in association with peroxisome proliferator-activated receptor gamma (PPAR-γ)-related signaling involved in lipid metabolism.

LINC00963/miR-4458 Regulates the Effect of Oxaliplatin in Gastric Cancer by Mediating Autophagic Flux through Targeting of ATG16L1

[Scientific Reports] Investigators found that LINC00963 was aberrantly highly expressed in oxaliplatin-resistant SGC-7901 (SGC-7901-R) cells and promoted proliferation and migration and reduced the apoptosis rate in SGC-7901-R cells.

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