cell proliferation

[Human Pathology] The apoptosis of smooth muscle cells is a major feature of thoracic aortic aneurysm. Scientists investigated the roles of circ_0091434 in human aortic smooth muscle cells.

[Biomedical Materials] The authors demonstrated that the proliferation of keratinocytes and their secretion of cytokines and growth factors could be activated through appropriate electrical stimulation to benefit skin wound healing.

[Cell Death Discovery] Researchers showed that the transcripts of Gadd45 family genes, including Gadd45a, Gadd45b, and Gadd45g, were gradually increased upon mouse ESC differentiation. Upregulation of Gadd45 members decreased cell proliferation and induced endodermal and trophectodermal lineages.

[Cell Death Discovery] The Transwell assay and xenograft nude model showed that LHPP inhibited migration and invasion of colorectal cancer cells in vitro and in vivo, respectively. The expression of total and nuclear epithelial-to-mesenchymal transition-related proteins were significantly reduced after LHPP upregulation.

[Cytotherapy] The authors revealed a strategy to modulate CAR T-cell activity at the protein level by employing Escherichia coli dihydrofolate reductase and trimethoprim as a chemical switch system.

[Acta Pharmaceutica Sinica B] Scientists demonstrated that physapubenolide (PB) inhibited cell proliferation and migration in melanoma cells by inducing cell apoptosis. They explored the mechanism underlying the anticancer effects of PB through an in silico target prediction study.