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cell proliferation

MCM2-7 Complex Is a Novel Druggable Target for Neuroendocrine Prostate Cancer

[Scientific Reports] Inhibition of MCM2-7 by treatment with ciprofloxacin inhibits neuroendocrine prostate cancer (NEPC) cell proliferation and migration in vitro, significantly delays NEPC tumor xenograft growth, and partially reverses the neuroendocrine phenotype in vivo.

Circ_0002984 Induces Proliferation, Migration and Inflammation Response of VSMCs Induced by Ox-LDL through miR-326-3p/VAMP3 Axis in Atherosclerosis

[Journal of Cellular and Molecular Medicine] The authors investigated the function of circ_0002984 in vascular smooth muscle cells (VSMCs) incubated by oxidized low-density lipoprotein (ox-LDL). Loss of circ_0002984 suppressed VSMC viability, cell cycle distribution and migration capacity.

Combination of Retinoids and Narrow-Band Ultraviolet B Inhibits Matrix Metalloproteinase 13 Expression in HaCaT Keratinocytes and a Mouse Model of Psoriasis

[Scientific Reports] Scientists showed that patients with psoriasis had increased levels of matrix metalloproteinase13 protein in skin lesions and serum samples.

LncRNA CERS6-AS1 Promotes Proliferation and Metastasis through the Upregulation of YWHAG and Activation of ERK Signaling in Pancreatic Cancer

[Cell Death & Disease] Scientists found that lncRNA CERS6-AS1 was highly expressed in pancreatic cancer tissues and cells. Additionally, high expression of CERS6-AS1 was obviously associated with poor prognosis.

ENO1 Promotes Lung Cancer Metastasis via HGFR and WNT Signaling-Driven Epithelial-Mesenchymal Transition

[Cancer Research] Reserachers found that high expression of α-enolase was present in metastatic lung cancer cell lines and malignant tumors and was associated with poor overall survival of lung cancer patients.

The RNA m6A Reader YTHDF2 Controls NK Cell Antitumor and Antiviral Immunity

[Journal of Experimental Medicine] The authors discovered that YTHDF2, a well-known N6-methyladenosine (m6A) reader, was upregulated in NK cells upon activation by cytokines, tumors, and cytomegalovirus infection.

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