chronic inflammation

[Scientific Reports] Scientists characterized circulating extracellular vesicles and provided supporting data on their potential use as novel surrogate biomarkers for primary sclerosing cholangitis.

[Journal of Leukocyte Biology] Researchers hypothesized that cystic fibrosis airway neutrophils contributed to chronic inflammation, in part, via the packaging of inflammasome-inducing signals in extracellular vesicles.

[Journal of Dermatological Science] Researchers investigated whether miR-155 regulated glycolysis of psoriasis and the underlying mechanisms. Human dermal-derived MSCs were treated with miR-155 mimic or inhibitor, followed by assessments of cells proliferation, metabolism and inflammatory response.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists examined the impact of Hurricane Maria and its aftermath on immune cell gene expression in large, age-matched, cross-sectional samples from free-ranging rhesus macaques living on an isolated island.

[Cell Biochemistry and Biophysics] The authors investigated the effect of fatty acid binding protein 4 (FABP4) on lipogenesis in human skeletal muscle cells stimulated by Interleukin-4 and explored the mechanistic basis.

[NPJ Regenerative Medicine] Isolated matrix-bound nanovesicles (MBV) were delivered via intravenous or peri-articular injection to rats with pristane-induced arthritis. The results of MBV administration were compared to intraperitoneal administration of methotrexate, the clinical standard of care.