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colorectal cancer

Development of a Hybrid Nanoink for 3D Bioprinting of Heterogeneous Tumor Models

[ACS Biomaterials Science & Engineering] Scientists reported a hybrid nanoink composed of alginate, gelatin methacryloyl, and cellulose nanocrystal, designed for multinozzle microextrusion 3D printing of tumor models.

Long Non-Coding RNA TPT1-AS1 Suppresses APC Transcription in a STAT1-Dependent Manner to Increase the Stemness of Colorectal Cancer Stem Cells

[Molecular Biotechnology] Stem cells from colorectal cancer HCT116 and CACO2 cells were isolated. TPT1-AS1 was significantly highly expressed in the CSCs compared to non-stem cells.

Anti-miR-135/SPOCK1 Axis Antagonizes the Influence of Metabolism on Drug Response in Intestinal/Colon Tumor Organoids

[Oncogenesis] The authors analyzed the expression of 373 miRNAs and 12 deregulated metabolic genes in murine duodenal polyps and non-polyp-derived organoids.

Loss of Circadian Gene Timeless Induces EMT and Tumor Progression in Colorectal Cancer via Zeb1-Dependent Mechanism

[Cell Death & Differentiation] Genome-wide expression profiling, in vitro and in vivo experiments, revealed that Timeless knockdown induced the activation of the epithelial-to-mesenchymal transition program.

Highly Efficient PD-1-Targeted CRISPR-Cas9 for Tumor-Infiltrating Lymphocyte-Based Adoptive T Cell Therapy

[Molecular Therapy Oncolytics] Non-viral/plasmid-based programmed cell death protein 1 (PD-1) knockout was carried out immediately prior to the traditional 14-day tumor-infiltrating lymphocytes-based ACT rapid expansion protocol.

AMIGO2 Contained in Cancer Cell-Derived Extracellular Vesicles Enhances the Adhesion of Liver Endothelial Cells to Cancer Cells

[Scientific Reports] Scientists explored the role of cancer cell-derived amphoterin-induced gene and open reading frame 2 (AMIGO2)-containing extracellular vesicles in the adhesion of cancer cells to human hepatic sinusoidal endothelial cells.

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