COVID-19

[Immunity] Researchers interrogated the brain stem and olfactory bulb in COVID-19 patients postmortem using imaging mass cytometry to understand the local immune response at a spatially resolved, high-dimensional single-cell level and compared their immune map to non-COVID respiratory failure, multiple sclerosis and control patients.

[Hypertension Research] After the COVID-19 era, the novel vaccine technology developed will expand to other vaccines. Scientists have been developing vaccines for chronic diseases, such as hypertension, for over ten years.

[Cell Discovery] Comparison of the transcriptomes of the bronchoalveolar microenvironment and peripheral blood indicates alveolar macrophages, alveolar epithelial cells, and monocytes in lungs as the potential main sources of elevated cytokines mediating systemic immune responses and organ damages.

[Nature Communications] Scientists demonstrated that despite the large size of the viral RNA genome, infectious full-length cDNA is readily assembled in vitro by a circular polymerase extension reaction methodology without the need for technically demanding intermediate steps.

[Nature Communications] To understand the structural basis for SARS-CoV-2 viral-host protein recognition, scientists used cryo-electron microscopy to determine a complex structure of the human cell junction protein PALS1 and SARS-CoV-2 viral envelope protein.

[Cardiovascular Drugs and Therapy] The clinical features of COVID-19, the central role of the endothelium in COVID-19 and in other pathologies, and the potential of specific therapies aimed at protecting the endothelium in COVID-19 patients are addressed.