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Pulmonary Cell NewsResearchers interrogated the brain stem and olfactory bulb in COVID-19 patients postmortem using imaging mass cytometry to understand the local immune response at a spatially resolved, high-dimensional single-cell level and compared their immune map to non-COVID respiratory failure, multiple sclerosis and control patients.
[Immunity]
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Schwabenland, M., Salié, H., Tanevski, J., Killmer, S., Lago, M. S., Schlaak, A. E., Mayer, L., Matschke, J., Püschel, K., Fitzek, A., Ondruschka, B., Mei, H. E., Boettler, T., Neumann-Haefelin, C., Hofmann, M., Breithaupt, A., Genc, N., Stadelmann, C., Saez-Rodriguez, J., … Bengsch, B. (2021). Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.06.002 Cite
