COVID-19

[Science Translational Medicine] Investigators showed that early-phase SARS-CoV-2 spike protein–specific immunoglobulin G (IgG) in serum of critically ill COVID-19 patients induces excessive inflammatory responses by human alveolar macrophages.

[Science Advances] The authors report ed cryo-EM structures of both trimeric spike ectodomains in complex with the 47D11 Fab. 47D11 bound to the closed receptor-binding domain, distal to the ACE2 binding site.

[STAT News] With COVID-19 suppression measures like mask wearing, school closures, and travel restrictions driving flu transmission rates to historically low levels around the world, it appears that one of the H3N2 clades may have disappeared — gone extinct.

[Lancet] Colchicine is an oral anti-inflammatory medication beneficial in gout, pericarditis, and coronary disease. Scientists investigated the effect of colchicine on the composite of COVID-19-related death or hospital admission.

[Heliyon] Researchers ivestigated the immune response in acute or convalescent COVID19 patients. They characterized the peripheral blood mononuclear cells using flow cytometry and found that CD8+ T cells were significantly subsided in moderate COVID-19 and convalescent patients.

[Omeros Corporation] Omeros Corporation announced preliminary results from the second cohort of critically ill COVID-19 patients treated with narsoplimab in Bergamo, Italy.