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Pulmonary Cell NewsInvestigators showed that early-phase SARS-CoV-2 spike protein–specific immunoglobulin G (IgG) in serum of critically ill COVID-19 patients induces excessive inflammatory responses by human alveolar macrophages.
[Science Translational Medicine]
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Hoepel, W., Chen, H.-J., Geyer, C. E., Allahverdiyeva, S., Manz, X. D., Taeye, S. W. de, Aman, J., Mes, L., Steenhuis, M., Griffith, G. R., Bonta, P. I., Brouwer, P. J. M., Caniels, T. G., Straten, K. van der, Golebski, K., Jonkers, R. E., Larsen, M. D., Linty, F., Nouta, J., … Dunnen, J. den. (2021). High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages. Science Translational Medicine, 13(596). https://doi.org/10.1126/scitranslmed.abf8654 Cite
