dermal cells

[Journal of Immunology] The authors showed that CD4+ T cells from patients with psoriasis and psoriatic arthritis exhibit increased production of IL-17 but decreased expression of IL-2 and PD-1.

[Journal of Materials Chemistry B] Investigators selectively conjugated several skin protein-derived cell-targeting peptides, including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors.

[Stem Cell Reviews and Reports] Scientists provide an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human iPSCs derived from healthy and diseased subjects.

[Communications Biology] Reserachers studied transcriptome profiles of human nail units using polydactyly specimens. Single-cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6, respectively.

[Scientific Reports] Investigators examined whether mineralocorticoid receptor antagonists can ameliorate glucocorticoid receptor-mediated skin barrier dysfunction in normal human epidermal keratinocytes, reconstructed human epidermis, and subjects under psychological stress.

[Scientific Reports] The authors identified a natural acidic formulation to reduce skin pigmentation. The metabolite propionic acid was the most abundant fatty acid in the filtrate from Pluronic F68 fermentation of Cutibacterium acnes and reduced the DOPA-positive melanocytes by significantly inhibiting cellular tyrosinase activity via binding to the free fatty acid receptor 2.