emphysema

[Gene Therapy] The authors investigated the pulmonary transplantation of macrophages transgenic for alpha-1 antitrypsin (AAT) as a potential therapy for AAT deficiency-associated lung pathology.

[Ebiomedicine] Florescence-activated flow cytometry analysis, immunofluorescence and organoid culture system were performed to identify the β-catenin/Wnt-activated cells in Fam13a+/+ or Fam13a−/− mice exposed to CS.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that the expression level of FCH and double SH3 domains 1 (FCHSD1) was drastically increased in mice in response to elastase instillation, an experimental model of chronic obstructive pulmonary disease. FCHSD1 is a member of the F-BAR family with two SH3 domains.

[Teva Pharmaceuticals, Ltd.] Teva Pharmaceuticals, Ltd. announced its US launch of the first generic version of twice daily PERFOROMIST®,formoterol fumarate inhalation solution, 20 mcg/2 ML, indicated to treat bronchoconstriction in patients with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.

[Experimental & Molecular Medicine] Researchers evaluated the effect of Slit2 on the proliferation and migration of mouse lung epithelial cells and its role in regeneration in an emphysema lung mouse model.

[Scientific Reports] Researchers suggest that HHIP repressed aerobic glycolysis and airway smooth muscle cells hyperplasia, which might contribute to the increased airway remodeling in Hhip+/- mice.