epithelial cells

[Scientific Reports] Scientists tested whether sphingosine has any adverse effects in the respiratory tract when applied into isolated ventilated and perfused lungs. A four hour ex vivo lung perfusion run using minipig lungs was performed.

[Cell Death & Disease] How transketolase (TKT) functions in the intestinal epithelium remains to be elucidated. To address this question, researchers specifically deleted TKT in intestinal epithelial cells.

[Science] Researchers showed that low-density lipoprotein receptor—related protein 1 mediated cell surface binding and the endocytosis of serum amyloid A-retinol complexes in cultured cells.

[Science Translational Medicine] Investigators found that ectopic expression of microRNA-200c markedly enhanced the antitumor activity of CD8+ cytotoxic T lymphocytes during adoptive cell therapy in multiple mouse models.

[American Journal of Physiology-Cell Physiology] Scientists generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs.

[Scientific Reports] Scientists analyzed antimicrobial peptides (AMPs), which showed antibacterial and anti-inflammatory effects in insects, and some AMPs also exhibited anticancer efficacy. The insect-derived peptide poecilocorisin-1 (PCC-1) did not induce toxicity in the human epithelial cell line HaCaT, but its potential as an anticancer agent was confirmed through specific effects of antiproliferation, apoptosis, and cell cycle arrest in two melanoma cell lines, SK-MEL-28 and G361.