extracellular matrix

[Scientific Reports] The authors detected and quantified the Na+ depositions in the ECM of myocardial tissue, which were suggested to be bound by negatively charged glycosaminoglycan structures.

[Science Advances] Researchers developed fibrous hydrogel assemblies that were stabilized with photocrosslinking and displayed fiber density–dependent strain-responsive properties.

[Nature] Investigators showed that dietary palmitic acid, but not oleic acid or linoleic acid, promoted metastasis in oral carcinomas and melanoma in mice. Tumor-associated Schwann cells secreted a specialized proregenerative ECM, the ablation of which inhibited metastasis initiation.

[Cancer Research] Researchers revealed that delivery of miR-122 was associated with downregulation of key genes in involved in metastatic and cancer inflammation pathways, including several pro-inflammatory factors, matrix metalloproteinases, and other extracellular matrix degradation enzymes.

[Biomedical Materials] The authors prepared a functional cell derived extracellular matrix biomaterial enriched with VEGFA and bFGF, which induced endothelial differentiation of human umbilical cord MSCs and promoted angiogenesis, which may improve the healing effect of skin injury.

[Science Advances] Researchers aimed to identify the causal pathogenic mutation in an early-onset osteoarthritis family, followed by functional studies in human iPSCs in an in vitro organoid cartilage model.