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fibroblasts

Targeting Lysophospholipid Acid Receptor 1 and ROCK Kinases Promotes Antiviral Innate Immunity

[Science Advances] Investigators found that viral infection promoted the G protein–coupled receptor lysophosphatidic acid (LPA)1 expression, and LPA restrained type I/III interferon production through LPA1.

The Current Challenges on Spray-Based Cell Delivery to the Skin Wounds

[Tissue Engineering Part C-Methods] Keratinocytes, fibroblasts, melanocytes, and mesenchymal stem cells (MSCs) are promising cell sources for cell spray procedures. Scientists focus on the different types of cells and spray instruments used in cell delivery procedures.

Interleukin-34 Promotes Tumorigenic Signals for Colon Cancer Cells

[Cell Death Discovery] Scientists summarize the available data supporting the multiple effects of interleukin-34 in human colorectal carcinoma.

Transcriptional Landscape Associated with Triple Negative Breast Cancer (TNBC) Resistance to Neoadjuvant Chemotherapy Revealed by Single Cell RNA-Seq

[Molecular Therapy-Oncolytics] Scientists identified the transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy at the single cell level by analyzing publicly-available transcriptome data from more than 5,000 single cells derived from four extinction and four persistence patients, revealing remarkable tumor heterogeneity.

Hemicentin-1 Is an Essential Extracellular Matrix Component of the Dermal–Epidermal and Myotendinous Junctions

[Scientific Reports] Performing in situ hybridization and immunofluorescence analysis, researchers found that mouse Hmcn1 and Hmcn2 showed a complementary distribution throughout different tissues and developmental stages.

Blastocyst-Inspired Hydrogels to Maintain Undifferentiation of Mouse Embryonic Stem Cells

[ACS Nano] Investigators developed hydrogels that enabledmouse ESCs (mESCs) to maintain stemness in vitro in the absence of both leukemia inhibitory factor and mouse embryonic fibroblasts, two critical factors in the standard protocol for mESC maintenance.

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