fibroblasts

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.

[Nature Reviews Clinical Oncology] The clinical relevance of cancer-associated fibroblasts are summarized with an emphasis on their value as prognosis factors and therapeutic targets.

[Photodermatology, Photoimmunology & Photomedicine] Scientists clarified the relationship between Endo180 reduction and the decrease in type I collagen fibers observed in photoaged dermis.

[Cellular & Molecular Immunology] Scientists discuss the role of inflammation in initiating epigenetic alterations in immune cells, cancer-associated fibroblasts, and cancer cells and suggest how and when epigenetic interventions can be combined with immunotherapies to improve therapeutic outcomes.

[Science Translational Medicine] Scientists used a hypertrophic scarring mouse model in which Jun was overexpressed globally or specifically in α-smooth muscle or collagen type I–expressing cells to cause excessive extracellular matrix deposition by skin fibroblasts in the skin after wounding.

[Molecular Psychiatry] Researchers generated cortical organoids from skin fibroblasts of patients with 16p11.2 copy number varient to investigate impacted neurodevelopmental processes and showed that organoid size recapitulated macrocephaly and microcephaly phenotypes observed in the patients with 16p11.2 deletions and duplications.