fibroblasts

[EMBO Journal] The authors demonstrated that genetic depletion of αSMA+ myofibroblasts led to pleiotropic wound healing defects, including lack of reepithelialization, dampened angiogenesis, and heightened hypoxia.

[Burns & Trauma] Understanding the relationship between autophagy and skin wound healing may provide novel strategies for the clinical treatment of wound healing.

[Gastroenterology] Autochthonous murine models of pancreatic cancer (PC) and co-implanted allografts of murine PC cell lines with adipose-derived MSCs were used to assess the role of Muc5ac in stromal heterogeneity.

[Scientific Reports] Researchers demonstrated that fibroblast programmed death ligand-1 (PD-L1) may have promoted pulmonary fibrosis through both Smad3 and β-catenin signaling and may represent a novel interventional target for idiopathic pulmonary fibrosis.

[Scientific Reports] To identify novel drug targets and uncover potential mechanisms by which these drugs attenuate fibrosis, scientists performed an integrative ‘omics analysis of transcriptomic and proteomic responses to TGFβ1-stimulated lung fibroblasts.

[Scientific Reports] Gene knockout studies revealed that SOX2 was an essential factor for the generation of CSCs by HRASV12 in mouse and human fibroblasts.