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granulocytes

Lamin B1 Deletion in Myeloid Neoplasms Causes Nuclear Anomaly and Altered Hematopoietic Stem Cell Function

[Cell Stem Cell] Scientists showed that loss of nuclear lamin B1 (LMNB1) encoded on chromosome 5q, which was frequently deleted in myeloid neoplasms, induced defects in nuclear morphology and human HSCs function associated with malignancy.

Small Extracellular Vesicles from iPSC-Derived Mesenchymal Stem Cells Ameliorate Tendinopathy Pain by Inhibiting Mast Cell Activation

[Nanomedicine] Investigators explored the effect of small extracellular vesicles from induced pluripotent stem cell-derived MSCs on acute pain and investigated the underlying mechanisms.

The Suppressive Effects of Mer Inhibition on Inflammatory Responses in the Pathogenesis of LPS-Induced ALI/ARDS

[Science Signaling] In human pulmonary aortic endothelial cells,lipopolysaccharide (LPS) induced decreased in the amounts of endothelial nitric oxide synthase, thrombomodulin, and vascular endothelial–cadherin, which was blocked by treatment with UNC2250.

The Non-ELR CXC Chemokine Encoded by Human Cytomegalovirus UL146 Genotype 5 Contains a C-Terminal β-Hairpin and Induces Neutrophil Migration as a Selective CXCR2 Agonist

[PLoS Pathogens] Researchers investigated how the diversity of UL146 in Human cytomegalovirus affected its signaling and structural properties to understand why its genetic diversity is maintained across human populations.

Dendritic Cells a Critical Link to Alveolar Bone Loss and Systemic Disease Risk in Periodontitis: Immunotherapeutic Implications

[Periodontology 2000] Dendritic cells consist of multiple subsets that reside in the epithelium, connective tissues, and major organs.

Differential Impact of JUUL Flavors on Pulmonary Immune Modulation and Oxidative Stress Responses in Male and Female Mice

[Archives of Toxicology] The author discusses the increase in circulating follicular helper T cells seen in autoimmune settings and explores potential explanations for this phenomenon.

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