in vitro

[British Journal of Cancer] The authors report that ibuprofen diminished cancer cell stemness properties that include reducing the ALDH+ subpopulation, side population and sphere formation in three cancer types.

[Cell Reports] Researchers report that genetically clonal iPSCs derived from an acute myeloid leukemia patient and characterized by exceptionally high engraftment potential gave rise, upon hematopoietic differentiation, to a phenotypic hierarchy.

[Cell Death & Disease] The authors investigated the effects of transmembrane member 16A on intestinal epithelial barrier function in vitro.

[Cancers] The authors address the recent advances in in vitro colorectal carcinoma (CRC) model systems, ranging from conventional CRC patient-derived models, such as conditional reprogramming-based cell cultures, to more experimental and state-of-the-art models, such as cancer-on-chip platforms or liquid biopsy.

[Nature Communications] Scientists used genome editing to engineer a general platform to improve the safety of future human pluripotent stem cell-derived cell transplantation therapies.

[Cell Death & Disease] Spry1 knockdown in three BRAFV600-mutant cutaneous melanoma cell lines markedly induced cell cycle arrest and apoptosis, repressed cell proliferation in vitro, and impaired tumor growth in vivo.