induced pluripotent stem cells

[Bone Therapeutics] Bone Therapeutics and Implant Therapeutics announced the signing of a research evaluation agreement. The agreement will enable Bone Therapeutics to access, evaluate and materially transfer Implant Therapeutics’ iPSC lines, media, differentiation protocols and expertise.

[Acta Physiologica] Given the ability of SARS-COV-2 to infect human pluripotent stem cell-derived pancreatic cells in vitro and the presence of SARS-CoV-2 in pancreatic samples from COVID-19 patients strongly hints that SARS-CoV-2 can invade the pancreas and directly cause pancreatic injury and diabetes.

[Stem Cell Reviews and Reports] Understanding biological mechanisms involved in the long-term alcohol exposure-induced cardiotoxicity is pivotal to the discovery of therapeutic strategies. Cardiomyocytes derived from human pluripotent stem cells were treated with clinically relevant doses of ethanol for various durations up to five weeks.

[Advanced Healthcare Materials] Airway epithelial patches were engineered by differentiating human iPSC-derived airway progenitors into physiological proportions of ciliated and goblet cells on a silk fibroin–collagen vitrigel membrane composite biomaterial for transplantation in porcine tracheal defects ex vivo and in vivo.

[Scientific Reports] Scientists used human iPSCs and generated a developmental timeline by differentiating sporadic amyotrophic lateral sclerosis (sALS) iPSCs to neural progenitors and to motor neurons and comparing mitochondrial parameters with familial ALS and control cells at each developmental stage.

[Stem Cells and Development] To associate the quality of kidney organoid differentiation with predictive markers, a ranking system was developed based on the ratio of nephron structure determined by histological examination.