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influenza

A Recombinant Protein Containing Influenza Viral Conserved Epitopes and Superantigen Induces Broad-Spectrum Protection

[eLife] Scientists constructed a recombinant protein named NMHC which consist of influenza viral conserved epitopes and a superantigen fragment.

A Regulatory T Cell Signature Distinguishes the Immune Landscape of COVID-19 Patients from Those with Other Respiratory Infections

[Science Advances] Scientists compared the immune signature from hospitalized SARS-CoV-2ā€“infected patients to patients hospitalized prepandemic with influenza or respiratory syncytial virus.

Recruitment of Dendritic Cell Progenitors to Foci of Influenza A Virus Infection Sustains Immunity

[Science Immunology] The authors showed that effective induction of T cell responses against influenza A virus in mice requires reinforcement of the resident lung conventional dendritic cells (cDC) network by cDC progenitors.

Development of Molecular Clamp Stabilized Hemagglutinin Vaccines for Influenza a Viruses

[NPJ Vaccines] Scientists demonstrated that a modular trimerization domain known as the molecular clamp allows the efficient production and purification of conformationally stabilised prefusion hemagglutinin from a diverse range of influenza A subtypes.

Impaired HA-Specific T Follicular Helper Cell and Antibody Responses to Influenza Vaccination Are Linked to Inflammation in Humans

[eLife] By studying the breadth of anti-hemagglutinin (HA) IgG, serum cytokines, and B and T cell responses by flow cytometry before and after influenza vaccination, investigators showed that formation of circulating T follicular helper cells was associated with high-titre antibody responses.

Innate Immune Responses at the Asymptomatic Stage of Influenza a Viral Infections of Streptococcus pneumoniae Colonized and Non-Colonized Mice

[Scientific Reports] Researchers compared innate immune responses in the lungs of healthy colonized and non-colonized mice after Influenza A virus challenge at the initial asymptomatic stage of infection.

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