Impaired HA-Specific T Follicular Helper Cell and Antibody Responses to Influenza Vaccination Are Linked to Inflammation in Humans

By studying the breadth of anti-hemagglutinin (HA) IgG, serum cytokines, and B and T cell responses by flow cytometry before and after influenza vaccination, investigators showed that formation of circulating T follicular helper cells was associated with high-titre antibody responses.