insulin producing cells

[Scientific Reports] Scrt1 expression was controlled by the transcriptional repressor RE-1 silencing transcription factor (REST) and was increased in an in vitro reprogramming system of pancreatic exocrine cells to β-like cells.

[Proceedings of the National Academy of Sciences of the United States of America] The authors evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor to maintain glucose homeostasis in type 1 diabetic rodents.

[Frontiers in Bioengineering and Biotechnology] Scientists highlight the development of in vitro cell culture models that allow systematic studies of pancreatic cell mechanobiology in response to extracellular matrix proteins, biomechanical effects, soluble factor modulation of biomechanics, substrate stiffness, fluid flow and topography.

[Nature Communications] By leveraging the conjugation platform, scientists successfully engineered INS-1E, a β-cell line, to repurpose the insulin secretion machinery, which enabled the glucose-dependent secretion of protective immunomodulatory factor interleukin-10.

[Stem Cell Research & Therapy] Researchers discuss the current research advances in strategies to obtain insulin-producing cells from different precursor cells and in stem cell-based therapies for diabetes.

[Nature Communications] Using a culture system designed to mimic the physiological oxygenation of the pancreas, scientists demonstrated high viability and preserved endocrine and exocrine function in human pancreatic slices for at least 10 days after sectioning.