insulin

[Science Advances] Scientists genetically engineered MSCs with Exendin-4, a glucagon-like peptide-1 analog, and demonstrated their boosted cellular functions and antidiabetic efficacy in a type 2 diabetes mellitus mouse model.

[Experimental Dermatology] The silencing of long non-coding RNAs (lncRNA) MSC antisense RNA 1 (MSC-AS1) hindered cell proliferation, migration and epithelial-mesenchymal transition in vitro and tumor growth

[Molecular Medicine Reports] M2‑like tumor‑associated macrophages (TAMs) accelerated the metastasis and increased the stemness of anaplastic thyroid carcinoma cells, and the underlying mechanism may have been related to the section of insulin‑like growth factor by M2‑like TAMs, which activated the IR‑A/IGF1R‑mediated PI3K/AKT/mTOR signaling pathway.

[Science] Scientists found that resident macrophage deficiency prevents storage of lipids in adipocytes from wild-type and Ccr2–/– mice fed a high-fat diet, as well as hyperphagic leptin receptor–deficient mice.

[inflammopharmacology] The authors review the various molecular pathways, and genetic relevance of mRNA expression of fetuin-A which is correlated with progression of non-alcoholic fatty liver disease (NAFLD).

[Scientific Reports] Researchers revealed that angiopoietins, including angiopoietin-1 and angiopoietin-2 permitted the generation of islets from iPSCs with elevated glucose responsiveness, a hallmark of mature islets.