intestinal epithelial cells

[STAR Protocols] Investigators provided a detailed protocol for an autologous in vitro long-term 3D co-culture system of human intestinal CD4+ T cells and intestinal stem cells to study T cell-intestinal epithelial cell interactions during tissue development and inflammation.

[Stem Cell Research & Therapy] Intestinal organoids derived from mouse small intestine were treated with vitamin D3, and the effects on intestinal stemness and differentiation were evaluated using real-time PCR and immunofluorescence staining of the distinct lineage markers.

[Cellular and Molecular Gastroenterology and Hepatology] The authors determined the role of LPA receptor 5 (LPA5) in regulation of intestinal epithelial barrier. Human colonic epithelial cell lines were used to determine the LPA5-mediated signaling pathways that regulate epithelial barrier.

[EMBO Journal] Investigators showed that the YAP‐TEAD transcription factor is a key downstream effector of Wnt signaling in the intestine.

[International Journal of Biological Macromolecules] Researchers showed that SEPS increased the proliferation and survival of intestinal epithelial cells during dextran sulfate sodium stimulation.

[Nature Communications] Researchers identified microRNA-146a as a major negative regulator of colonic inflammation and associated tumorigenesis by modulating IL-17 responses.