Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsResearchers identified microRNA-146a as a major negative regulator of colonic inflammation and associated tumorigenesis by modulating IL-17 responses.
[Nature Communications]
6445218 ZKUMWBS2 items 1 apa 0 default asc 1 161511 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d1f484d4c2fc7cfb2d2a07278bd6e841%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22ZKUMWBS2%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Garo%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-23%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGaro%2C%20L.%20P.%2C%20Ajay%2C%20A.%20K.%2C%20Fujiwara%2C%20M.%2C%20Gabriely%2C%20G.%2C%20Raheja%2C%20R.%2C%20Kuhn%2C%20C.%2C%20Kenyon%2C%20B.%2C%20Skillin%2C%20N.%2C%20Kadowaki-Saga%2C%20R.%2C%20Saxena%2C%20S.%2C%20%26amp%3B%20Murugaiyan%2C%20G.%20%282021%29.%20MicroRNA-146a%20limits%20tumorigenic%20inflammation%20in%20colorectal%20cancer.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%281%29%2C%202419.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-22641-y%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-22641-y%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DZKUMWBS2%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MicroRNA-146a%20limits%20tumorigenic%20inflammation%20in%20colorectal%20cancer%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucien%20P.%22%2C%22lastName%22%3A%22Garo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amrendra%20K.%22%2C%22lastName%22%3A%22Ajay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mai%22%2C%22lastName%22%3A%22Fujiwara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Galina%22%2C%22lastName%22%3A%22Gabriely%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Radhika%22%2C%22lastName%22%3A%22Raheja%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chantal%22%2C%22lastName%22%3A%22Kuhn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brendan%22%2C%22lastName%22%3A%22Kenyon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathaniel%22%2C%22lastName%22%3A%22Skillin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryoko%22%2C%22lastName%22%3A%22Kadowaki-Saga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shrishti%22%2C%22lastName%22%3A%22Saxena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gopal%22%2C%22lastName%22%3A%22Murugaiyan%22%7D%5D%2C%22abstractNote%22%3A%22Chronic%20inflammation%20can%20drive%20tumor%20development.%20Here%2C%20we%20have%20identified%20microRNA-146a%20%28miR-146a%29%20as%20a%20major%20negative%20regulator%20of%20colonic%20inflammation%20and%20associated%20tumorigenesis%20by%20modulating%20IL-17%20responses.%20MiR-146a-deficient%20mice%20are%20susceptible%20to%20both%20colitis-associated%20and%20sporadic%20colorectal%20cancer%20%28CRC%29%2C%20presenting%20with%20enhanced%20tumorigenic%20IL-17%20signaling.%20Within%20myeloid%20cells%2C%20miR-146a%20targets%20RIPK2%2C%20a%20NOD2%20signaling%20intermediate%2C%20to%20limit%20myeloid%20cell-derived%20IL-17-inducing%20cytokines%20and%20restrict%20colonic%20IL-17.%20Accordingly%2C%20myeloid-specific%20miR-146a%20deletion%20promotes%20CRC.%20Moreover%2C%20within%20intestinal%20epithelial%20cells%20%28IECs%29%2C%20miR-146a%20targets%20TRAF6%2C%20an%20IL-17R%20signaling%20intermediate%2C%20to%20restrict%20IEC%20responsiveness%20to%20IL-17.%20MiR-146a%20within%20IECs%20further%20suppresses%20CRC%20by%20targeting%20PTGES2%2C%20a%20PGE2%20synthesis%20enzyme.%20IEC-specific%20miR-146a%20deletion%20therefore%20promotes%20CRC.%20Importantly%2C%20preclinical%20administration%20of%20miR-146a%20mimic%2C%20or%20small%20molecule%20inhibition%20of%20the%20miR-146a%20targets%2C%20TRAF6%20and%20RIPK2%2C%20ameliorates%20colonic%20inflammation%20and%20CRC.%20MiR-146a%20overexpression%20or%20miR-146a%20target%20inhibition%20represent%20therapeutic%20approaches%20that%20limit%20pathways%20converging%20on%20tumorigenic%20IL-17%20signaling%20in%20CRC.%22%2C%22date%22%3A%222021-04-23%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-021-22641-y%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-021-22641-y%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-23T18%3A56%3A22Z%22%7D%7D%5D%7D
Garo, L. P., Ajay, A. K., Fujiwara, M., Gabriely, G., Raheja, R., Kuhn, C., Kenyon, B., Skillin, N., Kadowaki-Saga, R., Saxena, S., & Murugaiyan, G. (2021). MicroRNA-146a limits tumorigenic inflammation in colorectal cancer. Nature Communications, 12(1), 2419. https://doi.org/10.1038/s41467-021-22641-y Cite
