intestinal epithelial cells

[International Journal of Clinical Oncology] Epidermal growth factor-like domain-containing protein 7 (EGFL7) was upregulated in several colorectal cancer cell lines as compared with normal intestinal epithelial cell line HIEC. Transfection of EGFL7 siRNA significantly decreased cell proliferation and invasion capacity of SW620 and LoVo cells.

[Mucosal Immunology] Researchers revealed that epithelial cells are a major source of elastolytic activity in healthy human colonic tissues and this activity is greatly increased in Inflammatory Bowel Disease patients, both in diseased and distant sites of inflammation.

[Journal of Crohn's and Colitis] The impact of ER stress induced by Thapsigargin on serine protease secretion was studied using either human intestinal cells lines or organoids.

[Inflammatory Bowel Diseases] IL-1β decreased the expression of the LXR target gene ABCA1 in cultured intestinal epithelial cells. The synthetic LXR agonist GW3965 led to a decreased nuclear positivity of the p65 subunit of nuclear factor kappa B, a phosphorylation ratio of the p44-42 mitogen-activated protein kinase, and the expression of CCL-28 and IL-8 in IL-1β-stimulated Caco-2 cells.

[Mucosal Immunology] Scientists review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19

[Molecular biology of the Cell] Scientists report the consequences of silencing desmocollin-2 (Dsc2) on intestinal epithelial cell barrier function in vivo using mice with inducible intestinal-epithelial specific Dsc2 knockdown.