The impact of ER stress induced by Thapsigargin on serine protease secretion was studied using either human intestinal cells lines or organoids.
[Journal of Crohn’s and Colitis]
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Tapias, N. S., Denadai-Souza, A., Rolland-Fourcade, C., Quaranta-Nicaise, M., Blanpied, C., Marcellin, M., Edir, A., Rolland, C., Cirillo, C., Dietrich, G., Alric, L., Portier, G., Kirzin, S., Bonnet, D., Mas, E., Burlet-Schiltz, O., Deraison, C., Bonnart, C., Vergnolle, N., & Barreau, F. (2021). Colitis-linked to endoplasmic reticulum stress induces trypsin activity affecting epithelial functions. Journal of Crohn’s and Colitis, jjab035. https://doi.org/10.1093/ecco-jcc/jjab035 Cite