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Pulmonary Cell NewsIL-1β decreased the expression of the LXR target gene ABCA1 in cultured intestinal epithelial cells. The synthetic LXR agonist GW3965 led to a decreased nuclear positivity of the p65 subunit of nuclear factor kappa B, a phosphorylation ratio of the p44-42 mitogen-activated protein kinase, and the expression of CCL-28 and IL-8 in IL-1β-stimulated Caco-2 cells.
[Inflammatory Bowel Diseases]
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Miranda-Bautista, J., Rodríguez-Feo, J. A., Puerto, M., López-Cauce, B., Lara, J. M., González-Novo, R., Martín-Hernández, D., Ferreiro-Iglesias, R., Bañares, R., & Menchén, L. (2021). Liver X Receptor Exerts Anti-Inflammatory Effects in Colonic Epithelial Cells via ABCA1 and Its Expression Is Decreased in Human and Experimental Inflammatory Bowel Disease. Inflammatory Bowel Diseases, izab034. https://doi.org/10.1093/ibd/izab034 Cite
