Scientists report the consequences of silencing desmocollin-2 (Dsc2) on intestinal epithelial cell barrier function in vivo using mice with inducible intestinal-epithelial specific Dsc2 knockdown.
[Molecular biology of the Cell]
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Raya-Sandino, A., Luissint, A.-C., Kusters, D. H. M., Narayanan, V., Flemming, S., Garcia-Hernandez, V., Godsel, L. M., Green, K. J., Hagen, S. J., Conway, D. E., Parkos, C. A., & Nusrat, A. (2021). Regulation of Intestinal Epithelial Intercellular Adhesion and Barrier Function by Desmosomal Cadherin Desmocollin-2. Molecular Biology of the Cell, mbc.E20-12-0775. https://doi.org/10.1091/mbc.E20-12-0775 Cite