leukemia

[Science Advances] Researchers conducted a genome-wide CRISPRi-based screening of super enhancers in ETO2-GLIS2+ acute megakaryoblastic leukemia.

[Cellular Signalling] Researchers found that PH domain leucine-rich repeat protein phosphatase1 (PHLPP1) deficiency enhanced Thr163 phosphorylation of Mcl-1, inhibited Mcl-1 degradation and maintained Mcl-1 protein expression level in myocardium and cardiomyocytes upon myocardial infarction or Dox treatment.

[Molecular Therapy] Researchers are now studying how to expand CAR T s technology beyond its use in conventional polyclonal αβ T cells to address limitations to the current therapy in cancer and applications beyond it.

[Frontiers in Immunology] Investigators explored the impact of epigenetic modifiers and differentiation agents on leukemia cell lines of B cell origin, as well as normal B cells.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors demonstrated that antibody-induced leukemia inhibitory factor (LIF) blockade remodeled the lung epithelial transcriptome in association with increased apoptosis.

[Nature Communications] To dissect the dynamic regulation of Runx1 in hematopoietic development, researchers analyzed its 3D chromatin conformation in mouse ESC differentiation cultures.