lupus

[Trends in Parasitology] Understanding that antibodies play central roles in malaria immunity and systemic lupus erythematosus, the authors discuss how autoreactive B cells contribute to malaria immunity but promote SLE pathology in the absence of malaria.

[Nature Reviews Rheumatology] Investigators review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis.

[Nature Communications] Researchers showed that administration of the A2A receptor agonist CGS-21680 depleted established CD11c+T-bet+ B cells in ehrlichial-infected mice, in a B cell-intrinsic manner.

[Journal of Clinical Investigation] Scientists explored the underlying biology in myeloid cells from healthy volunteers following in vivo placebo or nicotinamide riboside administration and subsequently tested the findings in vitro in monocytes extracted from subjects with systemic lupus erythematosus.

[Current Research in Translational Medicine] In a Phase I trial, nine biopsy-proven lupus nephritis patients refractory to standard treatments underwent systemic infusion of 2×106 allogeneic adipose-derived MSCs/kg and were followed for 12 months post-intervention.

[Stem Cells International] Scientists investigated the efficacy of miR-20a overexpressing adipose-derived stem cell transplantation in murine lupus nephritis and explored potential molecular mechanisms.