lymphocytes

[Connect Biopharma Holdings Limited] Connect Biopharma Holdings Limited reported positive topline results from the global Phase II clinical trial of CBP-201 administered subcutaneously to adult patients with moderate-to-severe atopic dermatitis.

[Molecular Imaging and Biology] NSG mice received subcutaneous injections of CD19+ human B cell leukemia cells expressing firefly luciferase in their left hind flank.

[Signal Transduction and Targeted Therapy] Golgi membrane protein 1 (GOLM1) was positively correlated with infiltrating tumor-associated macrophages expressed high levels of programmed death-ligand 1 (PD-L1) and CD8+ T cell suppression in hepatocellular carcinoma tissues.

[Journal of Experimental Medicine] Using single-cell RNA and ATAC sequencing, investigators showed that virus-responding CD4+ T cells lacking both Bcl6 and Blimp1 could differentiate into cells with transcriptomic, chromatin accessibility, and functional attributes of memory cells but not of follicular helper T cells.

[International Immunopharmacology] Scientists examined the efficacy of TY101 as an anti-tumor immune reagent combined with HMGN1and R848.

[Current Opinion in Immunology] The authors highlight recent studies focusing on cellular interactions that regulate tissue resident memory T cells establishment and function.