lymphocytes

[Cancer Research] The authors demonstrated that inhibition of fibroblast growth factor receptor 3 (FGFR3) in FGFR3-activated bladder cancer elevated PD-L1 protein levels by affecting its ubiquitination, thereby inhibiting the anti-tumor activity of CD8+ T cells.

[Proceedings of the National Academy of Sciences of the United States of America] Invariant natural killer T (iNKT) cells from peripheral blood and colonic mucosa were investigated during treated and untreated acute HIV-1 infection.

[Cell Death & Disease] The authors detected a higher concentration of CD73+ tumor-derived extracellular vesicles enriched in exosomes in central and peripheral body fluids of glioblastoma patients than in those of patients with other brain tumors.

[Science Advances] Scientists explored a critical role for programmed cell death 1 (PD-1) in brain tumor–initiating cells and uncovered a nonimmune resistance mechanism of patients with glioblastoma to PD-1– or programmed cell death ligand 1 (PD-L1)–blocking therapies.

[Advanced Science] Among various cell sources, FGL1/PD-L1 small extracellular vesicles (sEVs) derived from MSCs not only enriched FGL1/PD-L1 expression but also maintained the immunomodulatory properties of unmodified MSC sEVs.

[Frontiers in Endocrinology] The authors differentiated iPSC from one donor into dendritic cells, macrophages, endothelial cells, and β-cells, and engineered T cell avatars from the same donor to provide an in vitro platform to study genetic influences on critical cellular interactions.