lymphocytes

[mBio] To investigate the specific role of T cells in recovery from SARS-CoV-2 infections, researchers studied rhesus macaques that were depleted of either CD4+, CD8+, or both T cell subsets prior to infection.

[Journal of Clinical Investigation] Scientists showed that natural killer (NK)-cell suppression of T cells is associated with transient accumulation of NK cells within T cell-rich sites of the spleen during lymphocytic choriomeningitis virus infection.

[Stem Cell Research] Natural killer cells were isolated from human umbilical cord blood from a healthy newborn and reprogrammed by episomal vectors carrying reprograming factors L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1, and shRNA against p53 delivered using nucleofection.

[PLOS Neglected Tropical Diseases] A model of HTLV-1 and S. stercoralis coinfection in CD34+ umbilical cord blood hematopoietic stem cell engrafted humanized mice was established.

[Nature Immunology] The authors described a new autoregulatory loop whereby ThPOK bound to the SilThPOK to maintain its own long-term expression in CD4 T cells.

[Autophagy] Researchers mechanistically and functionally linked CD38 and LRRK2 as upstream activators of TFEB, a host defense transcription factor and the master transcriptional regulator of the autophagy/lysosome machinery.