LRRK2 Is Required for CD38-Mediated NAADP-Ca²⁺ Signaling and the Downstream Activation of TFEB (Transcription Factor EB) in Immune Cells

Researchers mechanistically and functionally linked CD38 and LRRK2 as upstream activators of TFEB, a host defense transcription factor and the master transcriptional regulator of the autophagy/lysosome machinery.