lymphocytes

[Celularity Inc.] Celularity Inc. announced the US FDA has granted Orphan Drug Designation for its investigational natural killer cell therapy, CYNK-101, for treatment of gastric/gastroesophageal junction cancer.

[Nature Communications] Researchers showed that a subset of Interleukin-10-releasing HMOX1+ myeloid cells, spatially localizing to mesenchymal-like tumor regions, drove T cell exhaustion and thus contributed to the immunosuppressive tumor microenvironment.

[Haematologica] Researchers studied the influence of anthropometric and body composition measurements on CAR-T-related immunotoxicity in 64 patients receiving CD19-directed CAR-T for relapsed/refractory B cell malignancies.

[Bone Marrow Transplantation] Investigators studied the relationship between human cytomegalovirus reactivation and adaptive NK cells in 70 patients monitored weekly until 100 days after hematopoietic stem cell transplantation

[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that citrulline administration was more efficient than arginine in increasing arginine plasma levels and restoring T cell mitochondrial function and proliferation while reducing sepsis-induced T regulatory cells and myeloid-derived suppressor cells expansion.

[Oncogene] Scientists demonstrate that activated T cells armed with anti-CD3 x anti-EGFR bispecific antibody increases tumor infiltrating lymphocytes and mediate anti-tumor cytotoxicity while decreasing tumor cell viability.