lymphocytes

[Haematologica] Researchers designed a CD34/CD3 bispecific T-cell engager (BiTE) and characterized its anti-leukemia potential in vitro, ex vivo and in vivo.

[Proceedings of the National Academy of Sciences of the United States of America] In the absence of IFN-γ, lung innate lymphoid cells (ILC12) from mice challenged with the A/California/04/2009 H1N1 virus, containing nonfunctional viral PB1-F2, initiated a robust IL-5 response, which also led to improved tissue integrity and increased survival.

[Science Signaling] The authors investigated whether Themis plays a direct role in cytokine signaling in mature T cells.

[Biophysical Journal] Researchers found that in addition to increased cell motility, cancer cells exploited the elevated actomyosin force generation to remodel ECM and to deplete important co-stimulatory receptors on antigen presenting cells, facilitating tumor progression.

[EMBO Journal] Researchers revealed Pax5-Jak2 as an important nuclear driver of leukemogenesis by maintaining phosphorylated STAT5 levels in the nucleus.

[Nature Communications] Scientists showed that IL-18 was a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier.