lymphoid cells

[Immunity] Although PD-1 and TIGIT are thought to regulate different costimulatory receptors, effectiveness of PD-1 or TIGIT inhibition in preclinical tumor models was reduced in the absence of CD226.

[iScience] Researchers designed a lipid nanoparticle-encapsulated, nucleoside-unmodified mRNA vaccine encoding the trimerized receptor binding domain and showed its robust capability in inducing broad and protective immune responses against wildtype and major variants of concern in the mouse model of SARS-CoV-2 infection.

[Cell Reports] Scientists showed that B cell responses remained T cell dependent in constitutive Wiskott-Aldrich syndrome protein (WASp)-deficient mice, whereas selective WASp deletion in germinal center B cells was sufficient to induce broad development of self-reactive antibodies and kidney pathology.

[NPJ Genomic Medicine] Investigators identified a recurrent mutation at position c.28 in the gene encoding the snRNA U2. This mutation was present in B cell derived tumors, as well as in prostate and pancreatic cancer, suggesting U2 c.28 constitutes a driver candidate associated with worse prognosis.

[Cancer Research] A novel T cell receptor (TCR)-associated non-canonical function of AGO2 represented, in addition to TCL1A-mediated TCR signal augmentation, another enhancer mechanism of an important deregulated growth pathway in T cell prolymphocytic leukemia.

[International Immunopharmacology] The authors revealed that sialic acid removal and loading with CSC antigens induced significant molecular, morphological, and functional changes in dendritic cells (DCs) and that this new DC identity may be considered for future combined immunotherapy strategies against breast tumors.