lymphoid cells

[Science Signaling] The authors investigated whether Themis plays a direct role in cytokine signaling in mature T cells.

[Biophysical Journal] Researchers found that in addition to increased cell motility, cancer cells exploited the elevated actomyosin force generation to remodel ECM and to deplete important co-stimulatory receptors on antigen presenting cells, facilitating tumor progression.

[EMBO Journal] Researchers revealed Pax5-Jak2 as an important nuclear driver of leukemogenesis by maintaining phosphorylated STAT5 levels in the nucleus.

[Nature Communications] Scientists showed that IL-18 was a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier.

[Mucosal Immunology] Most nucleoprotein-specific CD8 T cells in broncho-alveolar lavage and lung are tissue resident memory cells that express CD69 and downregulate CD45RA and CCR7.

[PDS Biotechnology Corporation] PDS Biotechnology Corporation announced the initiation of an Investigator-Initiated Trial, MC200710, for PDS0101 alone or in combination with the checkpoint inhibitor, KEYTRUDA®, in patients with HPV-associated oropharyngeal cancer at high risk of recurrence.