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macrophages
Human Immunology News
B Cells and Tertiary Lymphoid Structures as Determinants of Tumor Immune Contexture and Clinical Outcome
[Nature Reviews Clinical Oncology] Investigators review the phenotypic heterogeneity of intratumoral B cells and the importance of tertiary lymphoid structures (TLS) in their generation as well as the potential of B cells and TLS as prognostic and predictive biomarkers.
Pulmonary Cell News
The Expression of PD-1 Ligand 1 on Macrophages and Its Clinical Impacts and Mechanisms in Lung Adenocarcinoma
[Cancer Immunology Immunotherapy] In an in vitro study using lung cancer cell lines and human monocyte-derived macrophages, the conditioned medium from cancer cells was found to up-regulate programmed cell death-1 ligand 1 expression on macrophages via STAT3 activation.
Human Immunology News
Clinical Relevance of Tumor-Associated Macrophages
[Nature Reviews Clinical Oncology] Scientists examine the diversity of tumor-associated macrophages (TAM) in various cancer indications and how this heterogeneity is being revisited with the advent of single-cell technologies, and then explore the current knowledge on the functional roles of different TAM states and the prognostic and predictive value of TAM-related signatures.
Dermal Cell News
Alpha-7 Nicotinic Acetylcholine Receptor Agonist Alleviates Psoriasis-Like Inflammation through Inhibition of the STAT3 and NF-κB Signaling Pathway
[Cell Death Discovery] Researchers analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.
Muscle Cell News
Stent-Based Delivery of AAV2 Vectors Encoding Oxidation-Resistant ApoA1
[Scientific Reports] The authors investigated whether local delivery of adeno-associated viral (AAV) vectors expressing oxidation-resistant wild type apolipoprotein A1 (apoA1) preserved apoA1 functionality.
Extracellular Matrix News
Patient-Derived Pancreatic Cancer-on-a-Chip Recapitulates the Tumor Microenvironment
[Microsystems & Nanoengineering] The authors developed a tumor-chip device engineered to mimic the pancreatic ductal adenocarcinoma tumor microenvironment by incorporating patient-derived organoids and stromal cells, specifically pancreatic stellate cells and macrophages.