STRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism

The authors generated Strap intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments.
[Gastroenterology]
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RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer

Scientists performed transcriptional profiling of tumors from a Phase II clinical trial of platinum chemotherapy for advanced TNBC, revealing a gene expression signature that identified de novo chemorefractory tumors.
[Clinical Cancer Research]
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Implication of Human Endogenous Retrovirus W Family Envelope in Hepatocellular Carcinoma Promotes MEK/ERK-Mediated Metastatic Invasiveness and Doxorubicin Resistance

There is no report on the expression pattern and potential mechanism of Syncytin-1 in hepatocellular carcinoma (HCC). Functional experiments in vitro and in vivo demonstrated that Syncytin-1 enhanced cell proliferation, metastasis, and tumorigenicity in HCC.
[Cell Death Discovery]
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Probing the Signaling Requirements for Naive Human Pluripotency by High-Throughput Chemical Screening

The authors reported that MEK1/2 inhibitors could be replaced during maintenance of naive human pluripotency by inhibitors targeting either upstream or downstream kinases. Naive human ESCs maintained under these alternative conditions displayed elevated levels of ERK phosphorylation but retained genome-wide DNA hypomethylation and a transcriptional identity of the pre-implantation epiblast.
[Cell Reports]
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The Transcription Factor Slug Uncouples Pancreatic Cancer Progression from the Raf-Mek1/2-Erk1/2 Pathway

Scientists generated pancreatic cancer cells resistant to Mek1/2 inhibition, which were also resistant to KRAS and Erk1/2 inhibitors.
[Cancer Research]
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Integrin αVβ1 Regulates Procollagen I Production through a Non-canonical Transforming Growth Factor β Signaling Pathway in Human Hepatic Stellate Cells

Based on mRNA and protein expression profiling data, investigators found that αVβ1 integrin is the most abundant member of the αV integrin family in either quiescent or transforming growth factor β (TGF-β)1-activated primary human hepatic stellate cells.
[Biochemical Journal]
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Dissection of Two Routes to Naïve Pluripotency Using Different Kinase Inhibitors

Researchers use mass spectrometry to describe the molecular events triggered by inhibition of Mek1/2 and Gsk3 and inhibition of Cdk8/19 on ESCs.
[Nature Communications]
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FGFR2 Fusion Proteins Drive Oncogenic Transformation of Mouse Liver Organoids towards Cholangiocarcinoma

Tumor organoids and 2D cell lines derived from CCA lesions were addicted to FF signaling via Ras-Erk, regardless of FF identity or V565F mutation.
[Journal of Hepatology]
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Generation of Macrophages with Altered Viral Sensitivity from Genome-Edited Rhesus Macaque iPSCs to Model Human Disease

Researchers established iPSCs from the peripheral blood of rhesus macaques (Rh-iPSCs) by combining the Yamanaka reprograming factors and two inhibitors and differentiated the cells into functional macrophages through hematopoietic progenitor cells.
[Molecular Therapy-Methods & Clinical Development]
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SOX9 in Prostate Cancer Is Upregulated by Cancer-Associated Fibroblasts to Promote Tumor Progression through HGF/C-Met-FRA1 Signaling

An in vitro model of paracrine interaction between primary cancer-associated fibroblasts and prostate cancer (Pca) cells was applied to investigate the molecular mechanism of SOX9 upregulation during Pca progression.
[FEBS Journal]
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BH3 Mimetics Potentiate Pro-Apoptotic Activity of Encorafenib in BRAFV600E Melanoma Cells

Researchers investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib, a recently FDA-approved BRAFV600E inhibitor.
[Cancer Letters]
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