STRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism

The authors generated Strap intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments.