mesenchymal stem cells

[Science Advances] Using an immune “hot” mouse ovarian cancer model, scientists found that cancer-associated-MSCs drove CD8+ T cell tumor immune exclusion and reduced response to anti–PD-L1 immune checkpoint inhibitor via secretion of numerous chemokines.

[PLoS One] Researchers identified a role for MSC-extracellular vesicles in immune modulation and cellular salvage in a model of SARS-CoV-2 induced acute lung injury using pulmonary epithelial cells and exposure to cytokines or the SARS-CoV-2 receptor binding domain.

[Stem Cell Research & Therapy] Investigators compared the potential of human bone marrow MSCs cultured as 2D monolayers or 3D spheroids encapsulated in constructs of 3D-printed poly-L-lactide-co-trimethylene carbonate scaffolds and modified human platelet lysate hydrogels for bone regeneration.

[Journal of Molecular and Cellular Cardiology] Scientists tested if MSC secretome preserved myocardial transcriptome profile and whether MSC secretome from a certain source provided the optimal protection in donor hearts during cold storage.

[Stem Cell Research & Therapy] In recent years, the application of MSCs in rheumatic diseases has received increasing attention. The authors review the clinical progress in MSC application for the treatment of rheumatic diseases.

[Cellular & Molecular Biology Letters] Stem cells, exosomes, and biomimetic materials represent emerging technologies for osteoporosis treatment. Scientists review summarizes the latest developments in these three aspects.