microglia

[Nature Reviews Neurology] The authors focus on the emerging human evidence for an association between maternal immune activation and childhood neurodevelopmental disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder and Tourette syndrome.

[Glia] Scientists developed a simplified method to generate iPSC-derived human microglia and transplanted them into the brain via a transnasal route in immunocompetent mice, in combination with a colony stimulating factor 1 receptor antagonist.

[Stem Cell Reports] Investigators reported a new brain region-specific, microglia-containing organoid model by co-culturing human PSC-derived primitive neural progenitor cells and primitive macrophage progenitors.

[Journal of Experimental Medicine] Scientists review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis.

[Scientific Reports] Investigators determined how the microglial transcriptome was altered following modest changes to Spi1 expression in primary mouse microglia.

[Cell Death & Disease] Pharmacological blockage of NF-κB nuclear translocation by SN-50 prevented microglial activation and alleviated the damage of dopaminergic neurons induced by microglial DJ-1 deficiency in vivo and in vitro.