monocytes

[Laboratory Investigation] Based on the immunohistochemical analysis of breast cancer tissues from 497 patients, the authors demonstrated that matrix metalloproteinase 11 (MMP11) expression in mononuclear inflammatory cells was an independent negative prognostic factor in breast cancer, whereas MMP11 expression in tumor cells and fibroblasts was not associated with patient survival.

[Molecular Pharmaceutics] Investigators used an in vitro peristaltic pump setup that mimiced pulsatile blood flow to determine if immune cells took up particles under constant fluidic flow.

[Journal of Cellular Biochemistry] Researchers examined the role of Bcl2-associated athanogene (BAG3) to activate human fibroblasts in releasing cytokines capable of supporting tumor progression.

[Nature] The authors identified the metabolite and neurotransmitter GABA as a candidate signaling molecule synthesized and secreted by activated B cells and plasma cells.

[Cell Death Discovery] Mice were administered Resolvin D1 via the tail vein 3 and 4 days after stimulation with lipopolysaccharide.

[Science Immunology] Researchers investigated the human antibody repertoire, avidity maturation, epitope specificity, and function after immunization with a single dose of Vi-tetanus toxoid conjugate vaccine and after a booster with plain Vi polysaccharide.