monocytes

[Science Advances] Researchers showed that abnormal IL-36 production activated by NF-κB was an essential feature of mouse and human leukemic progenitor cells.

[Scientific Reports] Irbesartan suppressedmonocyte chemoattractant protein-1 (MCP-1) production and the accumulation of Ly6C+CCR2+ monocytes and fibrocytes in the inflamed colon, downregulated the expression of type 1 collagen and matrix metalloproteinase 9 and inhibited the development of intestinal fibrosis and tumors.

[Nature Communications] The authors analyzed CD127+ innate lymphoid cells (ILCs) and natural killer cells in intestinal lamina propria from healthy donors and Crohn’s disease patients and identified two populations of CD127+CD94+ ILCs, designated population A and B, that could be distinguished on the expression of CD117, CD18 and cytotoxic molecules.

[Immunity] Researchers examined how targeting pathways that inhibit the differentiation of inflammatory myeloid cells affect antitumor immunity.

[Blood Advances] The authors developed reproducible methods to derive, from human pluripotent stem cells, a population containing monocyte progenitors able to generate functional osteoclast cells. Within this population, they identified cells with monocyte and osteoclast progenitor activity based on CD11b and CD14 expression.

[Molecular Medicine Reports] The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line.