monocytes

[Cell] Scientists identified DC2.112 and DC2.315, two pan-protective yet poorly neutralizing human monoclonal antibodies that avidly bind to viral antigen on the surface of cells infected with arthritogenic and encephalitic alphaviruses.

[Pediatric Research] Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.

[Scientific Reports] Scientists tested whether selective hematopoietic upstream stimulatory factor 1 (USF1) deficiency could also beneficially impact the development of atherosclerosis. Absence of USF1 function in bone marrow-derived cells was associated with exacerbated blood leukocyte and peritoneal leukocyte lipid loading and an increased atherosclerosis susceptibility.

[Blood Cancer Journal] The authors found that interleukin-10 receptor (IL-10R) was overexpressed in most acute myeloid luekemia cells, and played an important role in promoting the stemness of leukemia cells.

[Molecular Medicine Reports] Human vascular smooth muscle cells were loaded with cholesterol and different concentrations of metformin. The expression levels of adhesion molecules were assessed via reverse transcription‑quantitative PCR and western blotting.

[Scientific Reports] Scientists sought to understand how the programmed death ligand 1 inhibitor durvalumab and the immunomodulatory agent pomalidomide regulate immune cell activation and function in patients with relapsed/refractory multiple myeloma.