monocytes

[Nature Communications] Researchers showed that pyruvate dehydrogenase kinase 1 (PDK1) acted as a targetable determinant of different metabolic states in AML.

[Cell Death & Disease] The authors performed flow cytometry and single-cell RNA sequencing to examine the immune cell landscape of excisional wounds from Angptl4+/+ and Angptl4−/− mice.

[Stem Cell Reports] The authors findings supported a direct role for SARS-CoV-2 in mediating endothelial inflammation in an ACE2-dependent or -independent manner.

[Clinical and Translational Medicine] Ten fresh human tissue samples from six patients, including primary tumor and adjacent non-tumoral samples and six metastases from different organs or tissues were evaluated using single-cell RNA sequencing.

[EMBO Journal] Scientists showed that the serine/threonine kinase AKT2 interacted with interferon regulatory factor 3 (IRF3) and phosphorylated it on Thr207, thereby attenuating IRF3 nuclear translocation in a 14-3-3ε-dependent manner and reducing induced type I interferon production.

[Nature Immunology] Researchers combined a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associated specific immune trajectories with upper airway viral containment.