myeloid cells

[Oncogene] Researchers discovered that the Notch1-c-myc-VCAM1 signaling axis initiates liver progenitor cell-driven hepatocarcinogenesis and metastasis, providing a preclinical model for HCC study.

[International Immunopharmacology] Scientists showed that downregulation of METTL3 in prostate cancer tumor-associated macrophages modulated macrophages toward an M2-like phenotype and that this modulation was mediated by activation of STAT6.

[Scientific Reports] Scientists hypothesized that infrapatellar fat pad-derived MSCs robust immunomodulatory therapeutic effects were largely exerted via their exosomal secretome by attenuating synoviocytes and macrophages pro-inflammatory activation.

[Stem Cell Research & Therapy] MSCs were comparable to N-acetylcysteine against acetaminophen (APAP)-induced liver failure by secreting hepatocyte growth factor with less regenerative retardation concerns, thus facilitating the application of MSCs in clinical therapy for APAP liver failure.

[Scientific Reports] Urethral stricture rats showed increased gene and protein expression of collagen I, collagen III, and TGFβ1R, while stromal vascular fraction cells administration contributed to decreased gene and protein expression of collagen I, collagen III, and TGFβ1R, in parallel with the improvement of vascularization and increased expression of vascular endothelial growth factor and basic fibroblast growth factor.

[NPG Asia Materials] Researchers developed gethacrylate gelatin (GelMA)/ECM hydrogel fibrous scaffolds that could recruit and enhance the differentiation of neural stem cells by electrospinning and decellularization techniques.