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myeloid cells

Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium

[Advances in Experimental Medicine and Biology] Researchers measured the levels of inflammation, fibrosis, apoptosis, and necrosis in endomyocardial biopsies and sera of nonischemic PVB19-positive and PVB19-negative dilated cardiomyopathy patients.

Neutrophils in Chronic Inflammatory Diseases

[Cellular & Molecular Immunology] The authors highlight the interaction of neutrophils with other cells in the context of chronic inflammation, the contribution of neutrophils to selected chronic inflammatory diseases, and possible future therapeutic strategies.

Citrulline Depletion by ASS1 Is Required for Proinflammatory Macrophage Activation and Immune Responses

[Molecular Cell] Investigators found that macrophage citrulline declined rapidly after interferon gamma (IFN-γ) and/or lipopolysaccharide stimulation, which was required for efficient proinflammatory signaling activation.

CD169+ Macrophages in Lymph Node and Spleen Critically Depend on Dual RANK and LTbetaR Signaling

[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that lymph node CD169+ macrophages were dependent on direct lymphotoxin beta receptor signaling.

Endothelial Thrombomodulin Downregulation Caused by Hypoxia Contributes to Severe Infiltration and Coagulopathy in COVID-19 Patient Lungs

[Ebiomedicine] Pulmonary endothelial cells become dysfunctional during COVID-19, showing a loss of thrombomodulin expression related to severe thrombosis and infiltration, and endothelial cell dysfunction might be caused by a pathologic condition in COVID-19 patient lungs rather than a direct infection with SARS-CoV-2.

Dapagliflozin Exerts Anti-inflammatory Effects via Inhibition of LPS-Induced TLR-4 Overexpression and NF-κB Activation in Human Endothelial Cells and Differentiated Macrophages

[European Journal of Pharmacology] The authors assessed the direct anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors dapagliflozin on two cell types involved in the process of atherogenesis.

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